Genetic aberrations and survival in plasma cell leukemia

Hodgkin’s Lymphoma Occurring Secondary to Autologous Stem Cell Transplantation in Plasma Cell Leukemia; A Case Report

Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...

Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia.

Telomere length is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL). In a B-CLL cohort of 152 patients, we analyzed telomere length, genomic aberrations, IGHV mutation status, CD38 and ZAP-70 expression to study the prognostic impact and associations among these factors. An inverse correlati...

Plasma cell leukemia in pregnancy.

A 35-year-old multigravida with a 24-week pregnancy presented with generalized weakness and altered sensorium for 2 weeks. Physical examination revealed pallor and an enlarged uterus corresponding to gestational age. Complete blood counts showed hemoglobin 81 g/L, white cell count 259 109/L, and platelet count 71 109/L. A review of peripheral blood film (see figure) displayed 90% plasma cells, ...

Plasma cell leukemia

Paciente do gênero feminino, 74 anos, procurou o hospital com quadro de insuficiência renal e lesões líticas em coluna vertebral, sendo feito diagnóstico de mieloma múltiplo IgG kappa. Na ocasião, observaram-se monossomia do cromossomo 13 e rearranjo do IgH no FISH. A paciente foi submetida a cinco ciclos de VMP (bortezomibe, melfalan e prednisona) com resposta com pleta; foi iniciada a manuten...

Plasma cell leukemia.